Andrea Leitch
Institute of Genetics and Cancer(GB)University of Edinburgh(GB)
Publications by Year
Research Areas
interferon and immune responses, DNA Repair Mechanisms, Microtubule and mitosis dynamics, Genetics and Neurodevelopmental Disorders, Inflammasome and immune disorders
Most-Cited Works
- → cGAS surveillance of micronuclei links genome instability to innate immunity(2017)1,657 cited
- → Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus(2006)883 cited
- → Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection(2006)670 cited
- → Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development(2012)457 cited
- → Clinical and Molecular Phenotype of Aicardi-Goutières Syndrome(2007)445 cited
- → Mutations in the pre-replication complex cause Meier-Gorlin syndrome(2011)250 cited
- → Defective removal of ribonucleotides from DNA promotes systemic autoimmunity(2014)218 cited
- → Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome(2011)208 cited
- → Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy(2014)180 cited
- → RNA:DNA hybrids are a novel molecular pattern sensed by TLR9(2014)158 cited