Joseph F. Johnston
Publications by Year
Research Areas
Protein Kinase Regulation and GTPase Signaling, Melanoma and MAPK Pathways, Computational Drug Discovery Methods, Cell death mechanisms and regulation, DNA and Nucleic Acid Chemistry
Most-Cited Works
- → Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase(1996)452 cited
- → Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway(1996)275 cited
- → Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides.(1992)260 cited
- → Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats(2002)235 cited
- → Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-(1996)178 cited
- → Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C- raf kinase supports an antisense mechanism of action in vivo(1996)138 cited
- Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.(2001)
- → A Phase I trial of h-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma(2001)101 cited
- → Selective Inhibition of A-Raf and C-Raf mRNA Expression by Antisense Oligodeoxynucleotides in Rat Vascular Smooth Muscle Cells: Role of A-Raf and C-Raf in Serum-Induced Proliferation(1997)47 cited
- → The Characterization of Atrial Natriuretic Peptide (ANP) Expression by Primary Cultures of Atrial Myocytes Using an ANP-Specific Monoclonal Antibody and an ANP Messenger Ribonucleic Acid Probe*(1987)24 cited