Rosemary Burke
University of Toronto(CA)Paddington Cat Hospital(AU)
Publications by Year
Research Areas
Microtubule and mitosis dynamics, Ubiquitin and proteasome pathways, Cancer-related Molecular Pathways, Protein Degradation and Inhibitors, Epigenetics and DNA Methylation
Most-Cited Works
- → Patient-derived organoids model treatment response of metastatic gastrointestinal cancers(2018)1,968 cited
- → Exploiting evolutionary steering to induce collateral drug sensitivity in cancer(2020)126 cited
- → MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma(2017)113 cited
- → Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19(2016)111 cited
- → 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors(2016)98 cited
- → Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)(2017)93 cited
- → Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)(2013)79 cited
- → Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells(2013)77 cited
- → Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders(2020)73 cited
- → Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen(2016)69 cited