Patrick Sin‐Chan
Regeneron (United States)(US)
Publications by Year
Research Areas
Chromatin Remodeling and Cancer, Epigenetics and DNA Methylation, Glioma Diagnosis and Treatment, MicroRNA in disease regulation, Cancer Genomics and Diagnostics
Most-Cited Works
- → Epigenomic alterations define lethal CIMP-positive ependymomas of infancy(2014)616 cited
- → Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors(2016)251 cited
- → Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling(2017)226 cited
- → Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR(2013)198 cited
- → Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis(2015)179 cited
- → CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity(2014)159 cited
- → A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor(2019)84 cited
- → A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes(2013)64 cited
- → Rare genetic coding variants associated with human longevity and protection against age-related diseases(2021)47 cited
- → Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors(2018)23 cited