Mario Grugni
CTI BioPharma (United Kingdom)(GB)
Publications by Year
Research Areas
Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Chemical Synthesis and Analysis, Synthesis and Reactions of Organic Compounds, Metal complexes synthesis and properties
Most-Cited Works
- → Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs(2002)90 cited
- → Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework(1997)79 cited
- → Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 2. Identification of (S)-N-(1-Phenylpropyl)-3-hydroxy-2- phenylquinoline-4-carboxamide (SB 223412)(1999)63 cited
- → 2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor(1996)47 cited
- → Stepwise Modulation of Neurokinin-3 and Neurokinin-2 Receptor Affinity and Selectivity in Quinoline Tachykinin Receptor Antagonists(2001)45 cited
- Central and peripheral analgesic agents: chemical strategies for limiting brain penetration in kappa-opioid agonists belonging to different chemical classes.(1995)
- → Stability of Boronic Esters to Hydrolysis: A Comparative Study(2009)34 cited
- → Facile and Efficient Syntheses of Novel (S)- and (R)-3-Fluoropyrrolidines and 3,3-Difluoropyrrolidine(1995)25 cited
- → Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists(1999)21 cited
- → Novel Bis-platinum Complexes Endowed with an Improved Pharmacological Profile(2009)17 cited