James J.‐W. Duan

Publications by Year

Research Areas

Cytokine Signaling Pathways and Interactions, Rheumatoid Arthritis Research and Therapies, Protease and Inhibitor Mechanisms, Synthesis and biological activity, Psoriasis: Treatment and Pathogenesis

Most-Cited Works

• → Complete Relative Stereochemistry of Maitotoxin(1996)144 cited
• → Iodine monobromide (IBr) at low temperature: enhanced diastereoselectivity in electrophilic cyclizations of homoallylic carbonates(1993)127 cited
• → Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships(2002)119 cited
• → Inhibition of Tumor Necrosis Factor-α-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats(2004)82 cited
• → Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo(2001)79 cited
• → Total Synthesis of (+)-Calyculin A and (−)-Calyculin B: Asymmetric Synthesis of the C(9−25) Spiroketal Dipropionate Subunit(1999)73 cited
• → Total Synthesis of (+)-Calyculin A and (−)-Calyculin B: Cyanotetraene Construction, Asymmetric Synthesis of the C(26−37) Oxazole, Fragment Assembly, and Final Elaboration(1999)69 cited
• → Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors(2003)64 cited
• → Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents(2008)56 cited
• → Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)(2006)53 cited