Thomas N. O’Connell
Pfizer (United States)(US)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Microbial Natural Products and Biosynthesis, Drug Transport and Resistance Mechanisms, Ubiquitin and proteasome pathways, Computational Drug Discovery Methods
Most-Cited Works
- → METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO(2005)200 cited
- → A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation(2016)95 cited
- → Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool(2013)86 cited
- → Solution-Based Indirect Affinity Selection Mass Spectrometry—A General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries(2014)77 cited
- → IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES(2005)67 cited
- → Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1. I. Fermentation, Isolation and Biological Activity.(1998)64 cited
- → Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design(2012)63 cited
- → CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES(2004)53 cited
- → Synthesis and structure–activity relationships of thiotetronic acid analogues of thiolactomycin(2001)41 cited
- → PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease(2020)40 cited