Dean Shannon
Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Antibiotic Resistance in Bacteria, Cancer therapeutics and mechanisms, Crystallography and molecular interactions, Marine Sponges and Natural Products, Synthetic Organic Chemistry Methods
Most-Cited Works
- → Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships(2008)222 cited
- → Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases(2015)87 cited
- → Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability(2014)80 cited
- → Studies Directed toward Asymmetric Synthesis of Cardioactive Steroids via Anionic Polycyclization(2002)36 cited
- → Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2(2017)25 cited
- → Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV(2015)21 cited
- → Studies directed toward the synthesis of reiswigin A: Total synthesis of (±)-epi-reiswigin A(2004)7 cited
- → Studies Directed Toward the Synthesis of Reiswigin A: Total Synthesis of (.+‐.)‐epi‐Reiswigin A.(2004)
- → CCDC 227050: Experimental Crystal Structure Determination(2004)
- → CCDC 1056364: Experimental Crystal Structure Determination(2015)