Joseph Ligutti
Amgen (United States)(US)
Publications by Year
Research Areas
Ion channel regulation and function, Nicotinic Acetylcholine Receptors Study, Receptor Mechanisms and Signaling, Cardiac electrophysiology and arrhythmias, Pain Mechanisms and Treatments
Most-Cited Works
- → Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel(2015)116 cited
- → Automated Tight Seal Electrophysiology for Assessing the Potential hERG Liability of Pharmaceutical Compounds(2004)80 cited
- → Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity(2017)67 cited
- → Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain(2011)54 cited
- → Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7(2017)52 cited
- → Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1(2016)51 cited
- → Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V(2018)49 cited
- → Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities(2017)49 cited
- → Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors(2016)42 cited
- → Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins(2020)41 cited