José Cosme
University of Manchester(GB)Henry Royce Institute(GB)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Computational Drug Discovery Methods, Fibroblast Growth Factor Research, Kruppel-like factors research
Most-Cited Works
- → Crystal structure of human cytochrome P450 2C9 with bound warfarin(2003)812 cited
- → Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone(2004)805 cited
- → Mammalian Microsomal Cytochrome P450 Monooxygenase(2000)691 cited
- → Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design(2010)261 cited
- → Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*(1996)173 cited
- → Engineering Microsomal Cytochrome P450 2C5 to Be a Soluble, Monomeric Enzyme(2000)169 cited
- → Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features(2000)117 cited
- → Microsomal P450 2C3 Is Expressed as a Soluble Dimer inEscherichia coliFollowing Modifications of Its N-terminus(1997)110 cited
- → Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans(1995)105 cited
- → Oxidative metabolism of lansoprazole by human liver cytochromes P450.(1995)79 cited