Jonathan D. Parsons
Northumbria University(GB)
Publications by Year
Research Areas
Cancer therapeutics and mechanisms, Antibiotic Resistance in Bacteria, Antibiotics Pharmacokinetics and Efficacy, Click Chemistry and Applications, Bioactive Compounds and Antitumor Agents
Most-Cited Works
- → Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships(2008)222 cited
- → Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase(2004)156 cited
- → Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase(2010)105 cited
- → Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance(2003)91 cited
- → Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds(2006)90 cited
- → In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class(2006)81 cited
- → 4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors(2009)27 cited
- → Structural and Kinetic Analyses of the Protease from an Amprenavir-Resistant Human Immunodeficiency Virus Type 1 Mutant Rendered Resistant to Saquinavir and Resensitized to Amprenavir(2000)19 cited
- → Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones(2012)16 cited
- → Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides(2012)15 cited