Tom R. Jones
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Synthesis and Reactions of Organic Compounds, Phosphodiesterase function and regulation, Synthesis and Biological Evaluation, Asthma and respiratory diseases
Most-Cited Works
- → Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)(2007)170 cited
- → Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.(1990)151 cited
- → Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor(1992)113 cited
- → Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability(1996)62 cited
- → Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor(2002)56 cited
- → Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists(1995)31 cited
- → Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters(2002)31 cited
- → L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition(2007)30 cited
- → Substituted (Pyridylmethoxy)naphthalenes as Potent and Orally Active 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Pharmacokinetics of L-739,010(1997)29 cited
- Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma.(1998)