Steve Jacobsen

Publications by Year

Research Areas

Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Cholinesterase and Neurodegenerative Diseases, Drug Transport and Resistance Mechanisms, Ubiquitin and proteasome pathways

Most-Cited Works

• → Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors(2009)133 cited
• → Neurofilament ELISA validation(2009)104 cited
• → Acylguanidines as Small-Molecule β-Secretase Inhibitors(2006)100 cited
• → Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets(2007)70 cited
• → Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability(2010)52 cited
• → Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the β-amyloid peptide(2005)45 cited
• → Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1′ substrate binding pocket(2007)36 cited
• → Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells(2019)33 cited
• → Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors(2009)27 cited
• → P3‐101: GSI‐953, a potent and selective gamma‐secretase inhibitor, modulates Abeta peptides in mice and humans: Translating the PK/PD biomarker relationships in different biological compartments between rodent and human(2008)10 cited