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Zdeněk Hostomský | doi.page

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Zdeněk Hostomský

Pfizer (United States)(US)

Publications by Year

Research Areas

PARP inhibition in cancer therapy, DNA Repair Mechanisms, HIV/AIDS drug development and treatment, HIV Research and Treatment, RNA and protein synthesis mechanisms

Most-Cited Works

→ Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase(1991)567 cited
→ The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site(1996)506 cited
→ Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1(2000)495 cited
→ Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361(2004)483 cited
→ Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial(2007)298 cited
→ Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase(2000)286 cited

→ Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors(2010)

267 cited

→ Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2(2010)258 cited

→ Dicaffeoylquinic and Dicaffeoyltartaric Acids Are Selective Inhibitors of Human Immunodeficiency Virus Type 1 Integrase(1998)210 cited

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.(2000)