Shon K. Booker

Publications by Year

Research Areas

Protein Kinase Regulation and GTPase Signaling, PI3K/AKT/mTOR signaling in cancer, Pharmacogenetics and Drug Metabolism, Liver physiology and pathology, Endoplasmic Reticulum Stress and Disease

Most-Cited Works

• → Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors(2019)690 cited
• → Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors(2011)119 cited
• → Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors(2008)90 cited
• → Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)(2015)80 cited
• → Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series(2012)74 cited
• → Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives(2011)60 cited
• → Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511(2012)50 cited
• → Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases(2012)49 cited
• → Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles(2006)47 cited
• → Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability(2011)44 cited