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Peter P. Roller | doi.page

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Peter P. Roller

National Institutes of Health(US)Frederick National Laboratory for Cancer Research(US)

Publications by Year

Research Areas

Chemical Synthesis and Analysis, Protein Kinase Regulation and GTPase Signaling, Monoclonal and Polyclonal Antibodies Research, Cell death mechanisms and regulation, Carbohydrate Chemistry and Synthesis

Most-Cited Works

→ Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction(2006)684 cited
→ Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors(2005)644 cited
→ Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization(2004)553 cited
→ Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.(1993)375 cited
→ Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database(2004)340 cited
→ Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening(2001)312 cited

→ Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins(2006)

294 cited

→ Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.(1976)268 cited

→ The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport.(1992)262 cited

→ Identification of Cell Binding Sites in the Laminin α1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides(1995)255 cited