Christopher Fotsch
Amgen (United States)(US)
Publications by Year
Research Areas
Hormonal Regulation and Hypertension, Metabolism, Diabetes, and Cancer, Pancreatic function and diabetes, Regulation of Appetite and Obesity, Carbohydrate Chemistry and Synthesis
Most-Cited Works
- → Enzyme-catalyzed organic synthesis: practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors(1993)290 cited
- → Mitigating Heterocycle Metabolism in Drug Discovery(2012)250 cited
- → Systematic Study of the Glutathione (GSH) Reactivity ofN-Arylacrylamides: 1. Effects of Aryl Substitution(2015)152 cited
- → Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides(2004)102 cited
- → Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate(2007)98 cited
- → Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors(2013)97 cited
- → Structure−Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists(2000)84 cited
- → Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles(2006)83 cited
- → Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)(2010)81 cited
- → Vinyllithium cyclizations with unactivated alkenes as internal electrophiles: stereoselective formation of substituted methylenecyclopentanes(1988)79 cited