Jonathan P. Hutchinson
GlaxoSmithKline (Poland)(PL)
Publications by Year
Research Areas
Advanced Fluorescence Microscopy Techniques, Bipolar Disorder and Treatment, Tryptophan and brain disorders, Peptidase Inhibition and Analysis, Protein Structure and Dynamics
Most-Cited Works
- → Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis(2016)157 cited
- → Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase(2015)66 cited
- → Development of a small molecule that corrects misfolding and increases secretion of Z α 1 ‐antitrypsin(2021)62 cited
- → Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase(2017)46 cited
- → Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation(2020)43 cited
- → Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry(2013)39 cited
- → Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties(2021)37 cited
- → Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis(2017)35 cited
- → Single-Molecule Detection Technologies in Miniaturized High-Throughput Screening: Fluorescence Intensity Distribution Analysis(2003)35 cited
- → Refolding and recognition of mitochondrial malate dehydrogenase by Escherichia coli chaperonins cpn 60 (groEL) and cpn10 (groES)(1994)32 cited