Maria-Jesus Ortiz-Ruiz
Merck (Germany)(DE)
Publications by Year
Research Areas
Cancer-related Molecular Pathways, Advanced Breast Cancer Therapies, Cancer Mechanisms and Therapy, Ubiquitin and proteasome pathways, Cytokine Signaling Pathways and Interactions
Most-Cited Works
- → A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease(2015)143 cited
- → Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19(2016)111 cited
- → Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening(2016)108 cited
- → Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases(2016)93 cited
- → Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen(2015)79 cited
- → Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential(2016)1 cited
- → Abstract PR02: Identification of a potent and selective chemical probe for exploring the role of CDK8/19 in cancer biology(2015)
- → Author response: Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases(2016)
- → Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19(2017)