Pedro M. García-Barrantes
Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Neuroscience and Neuropharmacology Research, Pharmacological Receptor Mechanisms and Effects, Ion channel regulation and function, Chemical Synthesis and Analysis
Most-Cited Works
- → Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design(2012)303 cited
- → A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity(2018)64 cited
- → Synthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agents(2013)60 cited
- → Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs(2016)57 cited
- → Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics(2014)54 cited
- → Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia(2015)53 cited
- → Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators(2018)50 cited
- → Discovery, Synthesis, and Preclinical Characterization ofN-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)(2016)45 cited
- → Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics(2015)23 cited
- → Anti-ulcerogenic properties of Quassia amara L. (Simaroubaceae) standardized extracts in rodent models(2011)21 cited