Darshan S. Sappal
Foghorn Therapeutics (United States)(US)
Publications by Year
Research Areas
Ubiquitin and proteasome pathways, Cell death mechanisms and regulation, Autophagy in Disease and Therapy, DNA Repair Mechanisms, Histone Deacetylase Inhibitors Research
Most-Cited Works
- → A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment(2018)441 cited
- → Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit(2010)145 cited
- → Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib(2010)103 cited
- → Biological characterization of MLN944: A potent DNA binding agent(2004)52 cited
- → Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways(2014)50 cited
- → Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome(2010)40 cited
- → The antiproliferative agent MLN944 preferentially inhibits transcription(2005)29 cited
- → Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma(2022)11 cited
- → Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome(2012)9 cited
- → 577 Characterization of the cellular mechanism of action of the first in class investigational inhibitor of the Ubiquitin Activating Enzyme, MLN7243(2014)8 cited