Punit P. Seth
Ionis Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
DNA and Nucleic Acid Chemistry, RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, RNA Research and Splicing
Most-Cited Works
- → Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice(2014)580 cited
- → The Medicinal Chemistry of Therapeutic Oligonucleotides(2016)396 cited
- → Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index(2019)315 cited
- → Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals(2008)264 cited
- → Single-Stranded siRNAs Activate RNAi in Animals(2012)255 cited
- → Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues(2010)209 cited
- → Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts(2015)192 cited
- → Targeted delivery of antisense oligonucleotides to pancreatic β-cells(2018)178 cited
- → SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain(2005)173 cited
- → Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver(2016)163 cited