Puay Leng Lee
Agency for Science, Technology and Research(SG)Genome Institute of Singapore(SG)
Publications by Year
Research Areas
PI3K/AKT/mTOR signaling in cancer, RNA modifications and cancer, Epigenetics and DNA Methylation, PARP inhibition in cancer therapy, Histone Deacetylase Inhibitors Research
Most-Cited Works
- → Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells(2007)897 cited
- → IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer(2022)566 cited
- → Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer(2018)269 cited
- → DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in Colorectal Cancer and Is a Therapeutic Target of Histone Modifications(2008)237 cited
- → IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel(2015)170 cited
- → Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy(2022)159 cited
- → Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence(2017)156 cited
- → PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy(2013)153 cited
- → B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer(2010)120 cited
- → A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines(2021)114 cited