Alan M. Mathiowetz
Pfizer (United States)(US)PRX Research
Publications by Year
Research Areas
Computational Drug Discovery Methods, Chemical Synthesis and Analysis, Protein Structure and Dynamics, Enzyme Structure and Function, Receptor Mechanisms and Signaling
Most-Cited Works
- → On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds(2011)376 cited
- → Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules(2017)153 cited
- → A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor(2022)146 cited
- → Are 2D fingerprints still valuable for drug discovery?(2020)138 cited
- → Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products(2015)134 cited
- → Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(2012)131 cited
- → Human liver glycogen phosphorylase inhibitors bind at a new allosteric site(2000)126 cited
- → Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation(2012)114 cited
- → Protein simulations using techniques suitable for very large systems: The cell multipole method for nonbond interactions and the Newton‐Euler inverse mass operator method for internal coordinate dynamics(1994)95 cited
- → Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes(2014)88 cited