Alan M. Mathiowetz

Publications by Year

Research Areas

Computational Drug Discovery Methods, Chemical Synthesis and Analysis, Protein Structure and Dynamics, Enzyme Structure and Function, Receptor Mechanisms and Signaling

Most-Cited Works

• → On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds(2011)376 cited
• → Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules(2017)153 cited
• → A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor(2022)146 cited
• → Are 2D fingerprints still valuable for drug discovery?(2020)138 cited
• → Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products(2015)134 cited
• → Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(2012)131 cited
• → Human liver glycogen phosphorylase inhibitors bind at a new allosteric site(2000)126 cited
• → Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation(2012)114 cited
• → Protein simulations using techniques suitable for very large systems: The cell multipole method for nonbond interactions and the Newton‐Euler inverse mass operator method for internal coordinate dynamics(1994)95 cited
• → Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes(2014)88 cited