Simon Blake
Publications by Year
Research Areas
Osteoarthritis Treatment and Mechanisms, Bone Metabolism and Diseases, Rheumatoid Arthritis Research and Therapies, Cell Adhesion Molecules Research, Monoclonal and Polyclonal Antibodies Research
Most-Cited Works
- → Injurious Mechanical Compression of Bovine Articular Cartilage Induces Chondrocyte Apoptosis(2000)366 cited
- → Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis(2000)219 cited
- → Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokines(2003)182 cited
- → Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate(2001)153 cited
- → A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys(2006)136 cited
- → Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro(2008)120 cited
- → Azepanone-Based Inhibitors of Human and Rat Cathepsin K(2001)102 cited
- → Mechanical injury potentiates proteoglycan catabolism induced by interleukin‐6 with soluble interleukin‐6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage(2009)99 cited
- → Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13(2008)94 cited
- → A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat(2002)78 cited