Lee Freiburger
University of British Columbia(CA)
Publications by Year
Research Areas
Protein Structure and Dynamics, Heat shock proteins research, Enzyme Structure and Function, thermodynamics and calorimetric analyses, Computational Drug Discovery Methods
Most-Cited Works
- → Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein(2014)155 cited
- → A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease(2015)113 cited
- → Efficient segmental isotope labeling of multi-domain proteins using Sortase A(2015)86 cited
- → Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme(2011)81 cited
- → Elucidating Protein Binding Mechanisms by Variable‐c ITC(2009)59 cited
- → Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle(2021)56 cited
- → Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network(2021)54 cited
- → A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer(2017)48 cited
- → Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6‘-N-Acetyltransferase,(2007)44 cited
- → Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites(2015)44 cited