Les A. Dakin

Publications by Year

Research Areas

Epigenetics and DNA Methylation, Chemical Synthesis and Reactions, Catalytic C–H Functionalization Methods, Synthetic Organic Chemistry Methods, Crystallization and Solubility Studies

Most-Cited Works

• → Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)(2013)258 cited
• → AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia(2013)243 cited
• → Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas(2016)218 cited
• → EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation(2014)148 cited
• → Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains(2016)118 cited
• → Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases(2012)100 cited
• → A Mild, Chemoselective Protocol for the Removal of Thioketals and Thioacetals Mediated by Dess−Martin Periodinane(2003)80 cited
• → [4 + 2]-Annulations of Chiral Organosilanes: Application to the Total Synthesis of Leucascandrolide A(2006)79 cited
• → Speciation and Mechanistic Studies of Chiral Copper(I) Schiff Base Precursors Mediating Asymmetric Carbenoid Insertion Reactions of Diazoacetates into the Si−H Bond of Silanes(2000)79 cited
• → Carbenoid insertions into the siliconhydrogen bond catalyzed by chiral copper (I) schiff base complexes(1998)74 cited