Jeremy L. Yap
Southern District Health Board(NZ)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Cell death mechanisms and regulation, Ubiquitin and proteasome pathways, Synthesis and biological activity, Melanoma and MAPK Pathways
Most-Cited Works
- → Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules(2016)92 cited
- → BRD4 Structure–Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536(2015)90 cited
- → Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics(2015)88 cited
- → The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak(2013)86 cited
- → Small‐Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics(2010)81 cited
- → The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition(2012)80 cited
- → Pharmacophore identification of c-Myc inhibitor 10074-G5(2012)78 cited
- → Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors(2012)58 cited
- → Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5(2013)56 cited
- → Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein(2016)46 cited