James Turkson
Cedars-Sinai Medical Center(US)
Publications by Year
Research Areas
Cytokine Signaling Pathways and Interactions, PI3K/AKT/mTOR signaling in cancer, Cancer Mechanisms and Therapy, Synthesis and biological activity, Cancer, Lipids, and Metabolism
Most-Cited Works
- → STATs in oncogenesis(2000)1,728 cited
- → Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells(1999)1,649 cited
- → Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis(2002)1,199 cited
- → Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity(2007)740 cited
- → Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation(1998)657 cited
- → STAT proteins: novel molecular targets for cancer drug discovery(2000)648 cited
- → Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression(2001)642 cited
- → Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways(2005)577 cited
- Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.(2003)
- → Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells(2006)564 cited