Savvas Kleanthous

Publications by Year

Research Areas

Blood Coagulation and Thrombosis Mechanisms, Atrial Fibrillation Management and Outcomes, Cardiac electrophysiology and arrhythmias, Nitric Oxide and Endothelin Effects, Coagulation, Bradykinin, Polyphosphates, and Angioedema

Most-Cited Works

• → Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine(2000)71 cited
• → Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides(2007)49 cited
• → Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs(2006)40 cited
• → Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs(2007)29 cited
• → Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs(2007)23 cited
• → Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors(2009)22 cited
• → The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs(2011)13 cited
• → Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs(2009)12 cited
• → Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs(2011)9 cited
• → Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor(2011)2 cited