Keith B. Ryther
Abbott (United States)(US)
Publications by Year
Research Areas
Nicotinic Acetylcholine Receptors Study, Cholinesterase and Neurodegenerative Diseases, Synthesis and Biological Evaluation, Receptor Mechanisms and Signaling, Ion channel regulation and function
Most-Cited Works
- → Functional Characterization of the Novel Neuronal Nicotinic Acetylcholine Receptor Ligand GTS-21 In Vitro and In Vivo(1997)192 cited
- → Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors(1998)131 cited
- → Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3 H-thiazol-(2 Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging(2008)91 cited
- → ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties(1997)78 cited
- → Structure−Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties(1997)67 cited
- → Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice(1998)62 cited
- → Structure−Activity Studies and Analgesic Efficacy ofN-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors(2007)57 cited
- → Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice(1998)53 cited
- → Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist(1998)40 cited
- → Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic(1998)37 cited