Hiroki Iwashita
Takeda (Japan)(JP)
Publications by Year
Research Areas
Cholinesterase and Neurodegenerative Diseases, Phosphodiesterase function and regulation, Asthma and respiratory diseases, Alzheimer's disease research and treatments, Ion channel regulation and function
Most-Cited Works
- → Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma(2001)289 cited
- → Increased Expression of the Human Ca2 +-activated Cl− Channel 1 (CaCC1) Gene in the Asthmatic Airway(2002)133 cited
- → 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability(2009)123 cited
- → A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease(2011)89 cited
- → Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders(2017)41 cited
- → Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders(2017)37 cited
- → Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice(2009)28 cited
- → Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist–Induced Rat Models of Schizophrenia(2018)28 cited
- → Role of Eosinophil Chemotactic Factor by T Lymphocytes on Airway Hyperresponsiveness in a Murine Model of Allergic Asthma(2006)27 cited
- → PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke(2022)23 cited