Thomas Luebbers
Roche (Switzerland)(CH)
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Asymmetric Synthesis and Catalysis, Cholinesterase and Neurodegenerative Diseases
Most-Cited Works
- → Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening(2000)378 cited
- → Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers(2017)219 cited
- → Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation(2007)160 cited
- → Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein(2011)85 cited
- → Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase(2009)69 cited
- → A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam−Lactone Scaffold. Synthesis and Antibacterial Properties(2011)68 cited
- → New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine(2004)55 cited
- → Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds(2011)48 cited
- → Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment(2015)48 cited
- → Diastereoselective Cobalt-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant(2006)48 cited