U. Obst-Sander
Roche (Switzerland)(CH)
Publications by Year
Research Areas
Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Blood Coagulation and Thrombosis Mechanisms, Chemical Synthesis and Analysis, Crystallography and molecular interactions
Most-Cited Works
- → Fluorine in Medicinal Chemistry(2004)1,536 cited
- → Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles(2004)148 cited
- → Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal‐Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand(2005)104 cited
- → A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions(2004)95 cited
- → A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values(2006)58 cited
- → Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib(2022)35 cited
- → Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors(2005)34 cited
- → Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors(2006)31 cited
- → Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket(2006)28 cited
- → Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity(2006)26 cited