Huw M. Nash
Aileron (United States)(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, DNA Repair Mechanisms, DNA and Nucleic Acid Chemistry, Click Chemistry and Applications, Computational Drug Discovery Methods
Most-Cited Works
- → Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy(2013)653 cited
- → Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily(1996)436 cited
- → A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer(1997)320 cited
- → Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression(2020)186 cited
- → The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution(1997)169 cited
- → A General Technique To Rank Protein−Ligand Binding Affinities and Determine Allosteric versus Direct Binding Site Competition in Compound Mixtures(2004)130 cited
- → Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases(2004)116 cited
- → Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development(2023)114 cited
- → An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries(2004)98 cited
- → Specific Binding of a Designed Pyrrolidine Abasic Site Analog to Multiple DNA Glycosylases(1998)97 cited