Amanda M. Olson

Publications by Year

Research Areas

PARP inhibition in cancer therapy, DNA Repair Mechanisms, Microtubule and mitosis dynamics, Cancer-related Molecular Pathways, Cancer therapeutics and mechanisms

Most-Cited Works

• → ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models(2007)764 cited
• → Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer(2008)266 cited
• → Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors(2015)262 cited
• → PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow(2018)251 cited
• → Discovery ofN-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor(2007)184 cited
• → Relative efficacy of a brief motivational intervention for college student drinkers.(2001)158 cited
• → Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents(2009)108 cited
• → Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)(2009)106 cited
• → Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors(2006)81 cited
• → Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer(2008)74 cited