Paul A. Brough
Granta Design (United Kingdom)(GB)
Publications by Year
Research Areas
Heat shock proteins research, Enzyme Structure and Function, Endoplasmic Reticulum Stress and Disease, Computational Drug Discovery Methods, ATP Synthase and ATPases Research
Most-Cited Works
- → NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis(2008)476 cited
- → 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer(2007)442 cited
- → Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design(2005)231 cited
- → Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone(2009)173 cited
- → Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues(2007)142 cited
- → Discovery and Development of Pyrazole-Scaffold Hsp90 Inhibitors(2006)141 cited
- Targeting Hsp90 for the treatment of cancer.(2006)
- → 3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone(2005)80 cited
- → Structure-based discovery of a new class of Hsp90 inhibitors(2005)78 cited
- → Off-Rate Screening (ORS) By Surface Plasmon Resonance. An Efficient Method to Kinetically Sample Hit to Lead Chemical Space from Unpurified Reaction Products(2014)75 cited