Zhaoning Zhu
Publications by Year
Research Areas
Computational Drug Discovery Methods, Alzheimer's disease research and treatments, Cholinesterase and Neurodegenerative Diseases, Chemical Synthesis and Analysis, Click Chemistry and Applications
Most-Cited Works
- → Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor(2012)151 cited
- → Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation(2009)121 cited
- → Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction(2012)99 cited
- → Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation(2012)56 cited
- → Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors(2011)53 cited
- → Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo(2011)52 cited
- → Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates(2016)42 cited
- → Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease(2012)38 cited
- → An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis(2022)37 cited
- → Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators(2011)34 cited