Ming Guo
Central South University(CN)Wuhan University(CN)Hunan Cancer Hospital(CN)Xiangya Hospital Central South University(CN)
Publications by Year
Research Areas
Cancer-related Molecular Pathways, Cell death mechanisms and regulation, Ubiquitin and proteasome pathways, Cancer therapeutics and mechanisms, Cancer-related molecular mechanisms research
Most-Cited Works
- → Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition(2008)652 cited
- → A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment(2011)267 cited
- → Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development(2017)194 cited
- → Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity(2023)88 cited
- → A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete, and Durable Tumor Regression in Mice(2013)34 cited