Mutsuko Sakai
Kyoto Institute of Technology(JP)
Publications by Year
Research Areas
Neuroscience and Neuropharmacology Research, Receptor Mechanisms and Signaling, Diabetes Treatment and Management, Neuropeptides and Animal Physiology, Peptidase Inhibition and Analysis
Most-Cited Works
- → Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors(2012)39 cited
- → SMP-534 inhibits TGF-β-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis(2005)24 cited
- → Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore(2010)23 cited
- → Discovery of NovelN-Substituted Oxindoles as Selective M1and M4Muscarinic Acetylcholine Receptors Partial Agonists(2013)22 cited
- → 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): A potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A(2011)20 cited
- → GPR91 antagonist and TGF-β inhibitor suppressed collagen production of high glucose and succinate induced HSC activation(2020)19 cited
- → Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M1 and M4 muscarinic acetylcholine receptors agonists(2015)19 cited
- → Chronic administration of DSP‐7238, a novel, potent, specific and substrate‐selective DPP IV inhibitor, improves glycaemic control and β ‐cell damage in diabetic mice(2009)18 cited
- → Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists(2014)17 cited
- → Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M4 muscarinic acetylcholine receptor agonists(2014)16 cited