Cheng Chang
Pfizer (United States)(US)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Receptor Mechanisms and Signaling, Phosphodiesterase function and regulation, Autoimmune and Inflammatory Disorders Research, Computational Drug Discovery Methods
Most-Cited Works
- → Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites(2007)146 cited
- → Anti-Malarial Drug Artesunate Attenuates Experimental Allergic Asthma via Inhibition of the Phosphoinositide 3-Kinase/Akt Pathway(2011)115 cited
- → Plasma Protein Binding of Challenging Compounds(2015)112 cited
- → Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors(2016)76 cited
- → Anti‐allergic action of anti‐malarial drug artesunate in experimental mast cell‐mediated anaphylactic models(2012)66 cited
- → Computational Models to Assign Biopharmaceutics Drug Disposition Classification from Molecular Structure(2007)63 cited
- → Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms(2013)51 cited
- → Quantitative PK–PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans(2011)42 cited
- → Systems approach reveals photosensitivity and PER 2 level as determinants of clock‐modulator efficacy(2019)38 cited
- → Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189(2018)38 cited