Donghong Xu
Cytokinetics (United States)(US)
Publications by Year
Research Areas
Cardiomyopathy and Myosin Studies, Cardiac electrophysiology and arrhythmias, Heart Failure Treatment and Management, Viral Infections and Immunology Research, Cardiac pacing and defibrillation studies
Most-Cited Works
- → The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin(1998)369 cited
- → Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin(2017)186 cited
- → Discovery ofOmecamtiv Mecarbilthe First, Selective, Small Molecule Activator of Cardiac Myosin(2010)111 cited
- → A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants(2022)59 cited
- → Discovery ofTirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator(2018)29 cited
- → Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function(2021)25 cited
- → Catalytic activity of carboxypeptidase B and of carboxypeptidase Y with anisylazoformyl substrates(1999)15 cited
- → Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans(2024)8 cited
- → Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study(2023)8 cited
- → In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor(2024)6 cited