Robert L. Hoffman
Calithera (United States)(US)
Publications by Year
Research Areas
COVID-19 Clinical Research Studies, Computational Drug Discovery Methods, Lung Cancer Research Studies, SARS-CoV-2 and COVID-19 Research, Cancer therapeutics and mechanisms
Most-Cited Works
- → Discovery of (10 R )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- 2H -8,4-(metheno)pyrazolo[4,3- h ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations(2014)574 cited
- → Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19(2020)523 cited
- → Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19(2021)288 cited
- → Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor(2021)172 cited
- → Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19(2020)159 cited
- → Lipophilic Efficiency: The Most Important Efficiency Metric in Medicinal Chemistry(2013)126 cited
- → Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib(2014)117 cited
- → Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer(2021)112 cited
- → Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists: Potential New Treatment for Migraine without Cardiovascular Side Effects(1998)84 cited
- → Asymmetric Synthesis of Cis-Fused Bicyclic Pyrrolidines and Pyrrolidinones via Chiral Polycyclic Lactams(1996)69 cited