Sahil Patel
Broad Institute(US)Harvard University(US)Massachusetts General Hospital(US)Harvard–MIT Division of Health Sciences and Technology(US)Pulmonary and Critical Care Associates(US)Massachusetts Institute of Technology(US)
Publications by Year
Research Areas
Cancer Genomics and Diagnostics, Enzyme Structure and Function, Single-cell and spatial transcriptomics, Protein Structure and Dynamics, Computational Drug Discovery Methods
Most-Cited Works
- → Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design(2010)261 cited
- → Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency(2007)211 cited
- → Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency(2010)185 cited
- → Apo and Inhibitor Complex Structures of BACE (β-secretase)(2004)178 cited
- → Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies(2024)148 cited
- → Application of Fragment Screening by X-ray Crystallography to β-Secretase(2007)144 cited