Sharadha Subramanian

Publications by Year

Research Areas

Melanoma and MAPK Pathways, Protein Kinase Regulation and GTPase Signaling, Cancer Mechanisms and Therapy, Computational Drug Discovery Methods, Synthesis and biological activity

Most-Cited Works

• → Discovery of Potent and Selective RSK Inhibitors as Biological Probes(2015)83 cited
• → Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors(2008)76 cited
• → Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma(2015)54 cited
• → Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers(2017)44 cited
• → Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis(2020)39 cited
• → Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3(2017)39 cited
• → Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic(2019)38 cited
• → Inhibition of prenylated KRAS in a lipid environment(2017)31 cited
• → Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors(2014)27 cited
• → 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors(2014)27 cited