Maxine Norman
Charles River Laboratories (United Kingdom)(GB)
Publications by Year
Research Areas
Retinoids in leukemia and cellular processes, Psoriasis: Treatment and Pathogenesis, Drug Transport and Resistance Mechanisms, Receptor Mechanisms and Signaling, Chemokine receptors and signaling
Most-Cited Works
- → Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action(2014)82 cited
- → Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists(2015)70 cited
- → Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc(2013)62 cited
- → Discovery of 1-{4-[3-Fluoro-4-((3 S ,6 R )-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist(2015)59 cited
- → Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists(2014)49 cited
- → A reversed sulfonamide series of selective RORc inverse agonists(2014)35 cited
- → Identification of tertiary sulfonamides as RORc inverse agonists(2014)27 cited
- → Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties(2016)15 cited
- → Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists(2015)10 cited
- → Using a Hybrid Approach for a Leadership Cohort Program(2013)3 cited