Adam J. Simon
AstraZeneca (Spain)(ES)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Computational Drug Discovery Methods, EEG and Brain-Computer Interfaces, Cholinesterase and Neurodegenerative Diseases
Most-Cited Works
- → Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects(2009)2,070 cited
- → Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects(2010)311 cited
- → Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)(2004)273 cited
- → Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease(2008)222 cited
- → Machine learning for comprehensive forecasting of Alzheimer’s Disease progression(2019)209 cited
- → A novel pathway for amyloid precursor protein processing(2009)168 cited
- → Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers(2010)140 cited
- → First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates(2008)105 cited
- → In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1(2007)100 cited
- → LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease(2006)94 cited