Martina M. Hughes
Queen Mary University of London(GB)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Tryptophan and brain disorders, Neuroinflammation and Neurodegeneration Mechanisms, Stress Responses and Cortisol, Calpain Protease Function and Regulation
Most-Cited Works
- → Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder(2012)174 cited
- → Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain(2016)141 cited
- → Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation(2012)105 cited
- → C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy(2013)94 cited
- → Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation(2010)93 cited
- → Stress-Related Immune Markers in Depression: Implications for Treatment(2016)85 cited
- → Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures(2017)65 cited
- → Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity(2021)26 cited
- → Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder(2014)21 cited
- → P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes(2023)17 cited