Paul Fraser
University Health Network(CA)University of Toronto(CA)German Center for Neurodegenerative Diseases(DE)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Cellular transport and secretion, Parkinson's Disease Mechanisms and Treatments, Wnt/β-catenin signaling in development and cancer, Prion Diseases and Protein Misfolding
Most-Cited Works
- → Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice(1997)1,262 cited
- → Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations(2005)323 cited
- → TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity(2006)296 cited
- → The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum(1996)228 cited
- → Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex(1999)222 cited
- → The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus(2012)192 cited