Neil MacLean
Princess Margaret Cancer Centre(CA)
Publications by Year
Research Areas
Acute Myeloid Leukemia Research, Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis
Most-Cited Works
- → Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia(2011)685 cited
- → Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality(2019)342 cited
- → Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia(2015)341 cited
- → AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress(2015)337 cited
- → The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma(2010)167 cited
- → Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors(2012)142 cited
- → Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production(2021)136 cited
- → RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs(2013)89 cited
- → Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia(2018)87 cited
- → The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness(2022)86 cited